Principles of Neural Science, Fifth Edition (Principles of Neural Science (Kandel))
Language: English
Pages: 1760
ISBN: 0071390111
Format: PDF / Kindle (mobi) / ePub
Now updated: the definitive neuroscience resource―from Eric R. Kandel, MD (winner of the Nobel Prize in 2000); James H. Schwartz, MD, PhD; Thomas M. Jessell, PhD; Steven A. Siegelbaum, PhD; and A. J. Hudspeth, PhD
A Doody's Core Title for 2015!
900 full-color illustrations
Deciphering the link between the human brain and behavior has always been one of the most intriguing―and often challenging―aspects of scientific endeavor. The sequencing of the human genome, and advances in molecular biology, have illuminated the pathogenesis of many neurological diseases and have propelled our knowledge of how the brain controls behavior.
To grasp the wider implications of these developments and gain a fundamental understanding of this dynamic, fast-moving field, Principles of Neuroscience stands alone as the most authoritative and indispensible resource of its kind.
In this classic text, prominent researchers in the field expertly survey the entire spectrum of neural science, giving an up-to-date, unparalleled view of the discipline for anyone who studies brain and mind. Here, in one remarkable volume, is the current state of neural science knowledge―ranging from molecules and cells, to anatomic structures and systems, to the senses and cognitive functions―all supported by more than 900 precise, full-color illustrations. In addition to clarifying complex topics, the book also benefits from a cohesive organization, beginning with an insightful overview of the interrelationships between the brain, nervous system, genes, and behavior. Principles of Neural Science then proceeds with an in-depth examination of the molecular and cellular biology of nerve cells, synaptic transmission, and the neural basis of cognition. The remaining sections illuminate how cells, molecules, and systems give us sight, hearing, touch, movement, thought, learning, memories, and emotions.
The new fifth edition of Principles of Neural Science is thoroughly updated to reflect the tremendous amount of research, and the very latest clinical perspectives, that have significantly transformed the field within the last decade.
Ultimately, Principles of Neural Science affirms that all behavior is an expression of neural activity, and that the future of clinical neurology and psychiatry hinges on the progress of neural science. Far exceeding the scope and scholarship of similar texts, this unmatched guide offers a commanding, scientifically rigorous perspective on the molecular mechanisms of neural function and disease―one that you’ll continually rely on to advance your comprehension of brain, mind, and behavior.
FEATURES
- The cornerstone reference in the field of neuroscience that explains how the nerves, brain, and mind function
- Clear emphasis on how behavior can be examined through the electrical activity of both individual neurons and systems of nerve cells
- Current focus on molecular biology as a tool for probing the pathogenesis of many neurological diseases, including muscular dystrophy, Huntington disease, and certain forms of Alzheimer’s disease
- More than 900 engaging full-color illustrations―including line drawings, radiographs, micrographs, and medical photographs clarify often-complex neuroscience concepts
- Outstanding section on the development and emergence of behavior, including important coverage of brain damage repair, the sexual differentiation of the nervous system, and the aging brain
- NEW! More detailed discussions of cognitive and behavioral functions, and an expanded review of cognitive processes
- NEW! A focus on the increasing importance of computational neural science, which enhances our ability to record the brain’s electrical activity and study cognitive processes more directly
- NEW! Chapter-opening Key Concepts provide a convenient, study-enhancing introduction to the material covered in each chapter
- Selected Readings and full reference citations at the close of each chapter facilitate further study and research
- Helpful appendices highlight basic circuit theory; the neurological examination of the patient; circulation of the brain; the blood-brain barrier, choroid plexus, and cerebrospinal fluid; neural networks; and theoretical approaches to neuroscience/ul>
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Placed in the presynaptic interneuron and two in the postsynaptic motor neuron. The current-passing electrode in the presynaptic cell is used to produce an action potential; in the postsynaptic cell it is used to alter the membrane potential systematically (using a current clamp) prior to the presynaptic input. B. Inhibitory actions counteract excitatory actions. 1. A large EPSP occurring alone moves the membrane potential toward E EPSP and exceeds the threshold for generating an action.
Is generated from the altered ES cell. (Adapted from Lewin 1994.) Mutations in the Gene Encoding a Serotonergic Receptor Intensify Impulsive Behavior Serotonin (5-hydroxytryptamine) is a monoamine that serves as a neurotransmitter in the brain. The level of serotonin is thought to be reduced in depressive illness. As we shall learn later (Chapter 44), neurons that synthesize serotonin are clustered in several nuclei in the brain stem, the most prominent of which are the raphe nuclei. Their.
Internal ear. The cylindrical hair cell is joined to the adjacent supporting cells by a junctional complex around its apical perimeter. From the cell's apical surface extends the hair bundle, the mechanically sensitive organelle. Afferent and efferent synapses occur upon the basolateral surface of the plasma membrane. B. This scanning electron micrograph of a hair cell's apical surface reveals the hair bundle protruding about 8 µm into the endolymph. The bundle comprises some 60 stereocilia,.
Extremities can be delineated in each premotor area (Figure 38-1C). However, unlike the primary motor cortex, where stimulation typically evokes simple movements of single joints, stimulation of the premotor areas often evokes more complex movements involving multiple joints and resembling natural coordinated hand shaping or reaching movements. Stimulation of the medial parts of area 6, the supplementary motor area, can give rise to bilateral movements, suggesting that this area has a role in.
Stretch and joint afferents and therefore stabilizes the head relative to the trunk (rather than to space). Consequently, when the trunk is stationary the vestibulocollic and cervicocollic reflexes collaborate in head stabilization. But when the trunk turns relative to the head, as when one looks at a fixed object while turning a corner, the cervicocollic reflex must be suppressed so that the vestibulocollic reflex alone stabilizes the head. Thus, even though innate, these reflexes can be.