Principles and Practice of Lung Cancer: The Official Reference Text of the International Association for the Study of Lung Cancer (IASLC) (4th Edition)

Principles and Practice of Lung Cancer: The Official Reference Text of the International Association for the Study of Lung Cancer (IASLC) (4th Edition)

Harvey I. Pass, David P. Carbone, David H. Johnson, John D. Minna, Giorgio V. Scagliotti, Andrew T. Turrisi

Language: English

Pages: 1053

ISBN: 2:00197653

Format: PDF / Kindle (mobi) / ePub


Thoroughly revised and updated, this Fourth Edition is the most comprehensive, current reference on lung cancer, with contributions from the world's foremost surgeons, radiation oncologists, medical oncologists, pulmonologists, and basic scientists. Coverage includes complete information on combined modality treatments for small cell and non-small cell lung cancer and on complications of treatment and management of metastases. Emphasis is also given to early detection, screening, prevention, and new imaging techniques.

This edition has expanded thoracic oncology chapters including thymus, mesothelioma, and mediastinal tumors, more detailed discussion of targeted agents, and state-of-the-art information on newer techniques in radiotherapy. Other highlights include more international contributors and greater discussion of changes in lung cancer management in each region of the world. A new editor, Giorgio Scagliotti, MD from the University of Turin, has coordinated the accounts of European activities.

A companion website includes the full text online and an image bank.

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EML4-ALK transforming gene in non-small cell lung cancer. Cancer Res 2008;68(13):4971–4976. 94 240. 241. 242. 243. 244. 245. 246. 247. 248. 249. 250. 251. 252. 253. SECTION 2 | LUNG CANCER BIOLOGY Perner S, Wagner PL, Demichelis F, et al. EML4-ALK fusion lung cancer: a rare acquired event. Neoplasia 2008;10(3):298–302. Inamura K, Takeuchi K, Togashi Y, et al. EML4-ALK fusion is linked to histological characteristics in a subset of lung cancers. J Thorac Oncol 2008;3(1):13–17. Koivunen.

Chromium exposure and smoking. Feng et al.126 noted that preexposure of normal human lung fibroblasts to chromium (VI) enhances the binding of benzo(a)pyrene diol epoxide to mutational hotspots in the p53 gene, specifically codons 248, 273, and 282. In the 1950s and 1960s, several steps were taken to decrease worker exposure to chromium—removal of calcium chromate by changing to lime-free processes and better environmental controls. Studies attempting to evaluate these modifications have not.

MTOR mTOR mTOR mTOR BCL2 BCL2 SRC Proteasome Proteasome p53 FUS1 HDACs HDACs Telomerase Cetuximab Panitumumab Matuzumab Gefitinib Erlotinib Lapatinib HKI-272 CI-1033 Trastuzumab Bevacizumab Cediranib Vandetanib Sunitinib Vatalanib Axitinib AMG-706 Imatinib Tipifarnib Lonafarnib Sorafenib CI-1040 PD-325901 AZD6244 LY294002 Sirolimus Temsirolimus Everolimus AP23573/deforolimus Oblimersen ABT-737 Dasatinib Bortezomib NPI-0052 p53 peptide vaccine Fus1 liposome complex Vorinostat Romidepsin GRN163L.

2008;17:645–654. Wistuba II, Gazdar AF, Minna JD. Molecular genetics of small cell lung carcinoma. Semin Oncol 2001;28:3–13. Zochbauer-Muller S, Minna JD, Gazdar AF. Aberrant DNA methylation in lung cancer: biological and clinical implications. Oncologist 2002;7:451–457. Siprashvili Z, Sozzi G, Barnes LD, et al. Replacement of Fhit in cancer cells suppresses tumorigenicity. Proc Natl Acad Sci U S A 1997; 94:13771–13776. Agathanggelou A, Cooper WN, Latif F. Role of the Ras-association domain.

Changes depending on the specific mutated site. Changes at the chromosomal level are usually detrimental since most likely affect large number of genes. Characterization of the genomic changes and identification of which molecular events contribute to the mechanisms that are central to tumorigenesis and to the multistep tumor progression are critical needs. Ultimately, the genomic discoveries will be translated into clinical tools that may impact the practice of cancer medicine. In this chapter,.

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